CNS tumor
CNS cysts
Ependymal (glioependymal) cyst

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 1 August 2018, last major update February 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: "Ependymal cyst"

Cite this page: Abdelzaher, E. Ependymal (glioependymal) cyst. website. Accessed December 15th, 2018.
Definition / general
  • Rare, benign intraparenchymal and often paraventricular cyst lined by simple epithelium, S100+ or GFAP+, resting on neuroglia
  • Usually intracranial, not midline but may affect spinal cord
  • Not in communication with ventricle or CSF spaces
  • Rarely ruptures and causes meningitis
Radiology images

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MR: cystic lesion of right frontal lobe

Case reports
Gross description
  • Resembles arachnoid cyst
Gross images

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Ependymal cyst

Microscopic (histologic) description
  • Simple columnar or cuboidal cells, often ciliated, resting on neuroglia
  • No fibrous capsule
Microscopic (histologic) images

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Collapsed cystic structure consisting
of thin fibrous wall lined by
flattened to cuboidal ependymal
cells with focal multilayering

Positive stains
Negative stains
Electron microscopy description
  • Neuroepithelial origin
Differential diagnosis