CNS tumor
CNS cysts
Ependymal (glioependymal) cyst



Topic Completed: 1 February 2012

Revised: 31 December 2018, last major update February 2012

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PubMed Search: "Ependymal cyst"


Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher E. Ependymal (glioependymal) cyst. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorependymal.html. Accessed August 24th, 2019.
Definition / general
  • Rare, benign intraparenchymal and often paraventricular cyst lined by simple epithelium, S100+ or GFAP+, resting on neuroglia
  • Usually intracranial, not midline but may affect spinal cord
  • Not in communication with ventricle or CSF spaces
  • Rarely ruptures and causes meningitis
Radiology images

Images hosted on other servers:

MR: cystic lesion of right frontal lobe

Case reports
Gross description
  • Resembles arachnoid cyst
Gross images

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Ependymal cyst

Microscopic (histologic) description
  • Simple columnar or cuboidal cells, often ciliated, resting on neuroglia
  • No fibrous capsule
Microscopic (histologic) images

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Collapsed cystic structure consisting
of thin fibrous wall lined by
flattened to cuboidal ependymal
cells with focal multilayering

Positive stains
Negative stains
Electron microscopy description
  • Neuroepithelial origin
Differential diagnosis
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