CNS tumor
Ependymal tumors
Clear cell ependymoma

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 30 August 2017, last major update August 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Ependymoma [title] clear cell

See also: GeneralCellularPapillaryTanycyticOther
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Cite this page: Abdelzaher, E. Clear cell ependymoma. website. Accessed December 6th, 2019.
Definition / general
  • Uncommon
  • Usually supratentorial
  • Age 3 - 31 years in one study (Am J Surg Pathol 1997;21:820)
  • Overall survival of 75% at 5 years
  • May have extraneural metastases and early recurrence
Case reports
Gross description
  • Well demarcated, deeply situated masses
  • May be dark red or resemble cyst with mural nodule, may be away from ventricle
Microscopic (histologic) description
  • Noninfiltrative growth, tumor cells have rounded nuclei with perinuclear clear halos and focal perivascular pseudorosettes
  • Large clefted and grooved nuclei
  • May have anaplastic features
Microscopic (histologic) images

Images hosted on other servers:

Above case history with giant cells

Representative histomorphology

Positive stains
Negative stains
  • Neuroendocrine markers
Electron microscopy description
  • Features of ependymoma
  • EM recommended for diagnosis of this variant - shows complex intercellular junctions, surface microvilli, cilia and microrosettes; no secretory granules, no vesicles, no synapses
Molecular / cytogenetics description
  • No deletions of 1p, 19q or NF2
Differential diagnosis
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