CNS tumor
Germ cell tumors

Topic Completed: 1 January 2006

Revised: 2 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Germ cell tumors [title] CNS

Nat Pernick, M.D.
Page views in 2019: 365
Page views in 2020 to date: 189
Cite this page: Pernick N. Germ cell tumors - general. website. Accessed May 29th, 2020.
Definition / general
  • < 2% of intracranial neoplasms in children or adults < 20 years old in US (50 new cases annually in US)
  • Higher frequency in Japan and Taiwan
  • 95% are midline in pineal or suprasellar regions, 10% involve both regions
  • Sacrococcygeal teratoma occurs at base of spine
  • Specimens are usually biopsies, not surgical resections
  • Divided into germinomas and nongerminomas
  • Germinomas have better prognosis than nongerminomas (Pediatr Neurol 2002;26:369)
  • Radiation therapy rarely causes cortical laminar necrosis (Pediatr Blood Cancer 2005;44:412)
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