CNS tumor
Germ cell tumors

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Germ cell tumors [title] CNS

Cite this page: Pernick, N. Germ cell tumors - general. website. Accessed July 23rd, 2018.
Definition / general
  • < 2% of intracranial neoplasms in children or adults < 20 years old in US (50 new cases annually in US)
  • Higher frequency in Japan and Taiwan
  • 95% are midline in pineal or suprasellar regions, 10% involve both regions
  • Sacrococcygeal teratoma occurs at base of spine
  • Specimens are usually biopsies, not surgical resections
  • Divided into germinomas and nongerminomas
  • Germinomas have better prognosis than nongerminomas (Pediatr Neurol 2002;26:369)
  • Radiation therapy rarely causes cortical laminar necrosis (Pediatr Blood Cancer 2005;44:412)