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CNS tumor
Astrocytic tumors
Glioblastoma multiforme

Reviewer: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 22 November 2013, last major update March 2012
Copyright: (c) 2005-2013, PathologyOutlines.com, Inc.

See subtypes below: small cell, giant cell, pediatric nonbrainstem

General
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Sites
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Clinical features
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Radiology
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Radiology images
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MRI sagittal view

With ring enhancement

Case reports
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Gross description
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Gross images
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Variegated tumor

Various images

Micro description
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Micro images
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Various images

Prominent anaplasia, vascular proliferation and palisading of tumor cells around necrosis


Pseudopalisading necrosis

Various vascular patterns

H&E and HAM56+ macrophages

Previous resection
and radiation therapy

Virtual slides
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Glioblastoma multiforme

Cytology images
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Figure 1

Figure 2

Necrosis


Fig 1: neoplastic astrocytes with cytoplasmic processes, nuclear atypia and mitotic figures
Fig 2: tufts of vascular proliferation resembling glomeruli

Positive stains
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Negative stains
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Molecular / cytogenetics description
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Differential diagnosis
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Small cell glioblastoma

General
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Giant cell glioblastoma

Definition
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Radiology
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Case reports
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Gross description
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Gross images
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Well circumscribed mass

Micro description
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Micro images
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Bizarre giant cells

Giant cells and smaller fusiform cells

Staining vs. pleomorphic xanthoastrocytoma




Case of Week #292: H&E and GFAP

Positive stains
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Negative stains
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Molecular / cytogenetics description
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Differential diagnosis
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Pediatric nonbrainstem glioblastomas

Definition
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Frequent molecular abnormalities detected by FISH

End of CNS tumor > Astrocytic tumors > Glioblastoma multiforme


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