CNS tumor
Diffuse astrocytic and oligodendroglial tumors
Glioblastoma-giant cell

Topic Completed: 1 March 2012

Minor changes: 25 September 2020

Copyright: 2002-2020, Inc.

PubMed Search: Giant cell glioblastoma [title]

Eman Abdelzaher, M.D., Ph.D.
Page views in 2019: 2,136
Page views in 2020 to date: 2,104
Cite this page: Abdelzaher E. Glioblastoma-giant cell. website. Accessed September 29th, 2020.
Definition / general
  • 5% of glioblastomas
  • Also affects younger individuals
  • May have better prognosis than classic glioblastoma
  • WHO grade IV
Radiology description
  • May mimic a metastasis
Case reports
Gross description
  • Circumscribed, firm, often subcortical mass
Gross images

Images hosted on other servers:

Well circumscribed mass

Microscopic (histologic) description
  • Abundant, bizarre appearing tumor giant cells, many multinucleated; smaller fusiform cells, extensive necrosis, brisk mitotic activity, abundant stromal reticulin, occasional perivascular lymphocyte cuffing
Microscopic (histologic) images

Case #292
H&E and GFAP H&E and GFAP H&E and GFAP H&E and GFAP

H&E and GFAP H&E and GFAP H&E and GFAP H&E and GFAP

H&E and GFAP

Positive stains
Negative stains
  • Neuronal markers
Molecular / cytogenetics description
  • p53 mutations in 75 - 90%, PTEN mutations in 1/3; EGFR amplification is rare
Differential diagnosis
Back to top
Image 01 Image 02