CNS tumor
Astrocytic tumors
Giant cell glioblastoma

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 6 June 2017, last major update March 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Giant cell glioblastoma [title]

Related topics: Glioblastoma multiforme
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Cite this page: Giant cell glioblastoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorglioblastomagiantcell.html. Accessed December 10th, 2019.
Definition / general
  • 5% of glioblastomas
  • Also affects younger individuals
  • May have better prognosis than classic glioblastoma
  • WHO grade IV
Radiology description
  • May mimic a metastasis
Case reports
Gross description
  • Circumscribed, firm, often subcortical mass
Gross images

Images hosted on other servers:

Well circumscribed mass

Microscopic (histologic) description
  • Abundant, bizarre appearing tumor giant cells, many multinucleated; smaller fusiform cells, extensive necrosis, brisk mitotic activity, abundant stromal reticulin, occasional perivascular lymphocyte cuffing
Microscopic (histologic) images

Images hosted on PathOut server:

Case of Week #292: H&E and GFAP



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Bizarre giant cells

Giant cells and smaller fusiform cells

Staining vs. pleomorphic xanthoastrocytoma

Positive stains
Negative stains
  • Neuronal markers
Molecular / cytogenetics description
  • p53 mutations in 75 - 90%, PTEN mutations in 1/3; EGFR amplification is rare
Differential diagnosis
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