CNS tumor
Astrocytic tumors
Giant cell glioblastoma

Topic Completed: 1 March 2012

Minor changes: 14 December 2019

Copyright: 2002-2019, Inc.

PubMed Search: Giant cell glioblastoma [title]

Eman Abdelzaher, M.D., Ph.D.
Page views in 2019: 2,136
Page views in 2020 to date: 1,125
Cite this page: Giant cell glioblastoma. website. Accessed June 1st, 2020.
Definition / general
  • 5% of glioblastomas
  • Also affects younger individuals
  • May have better prognosis than classic glioblastoma
  • WHO grade IV
Radiology description
  • May mimic a metastasis
Case reports
Gross description
  • Circumscribed, firm, often subcortical mass
Gross images

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Well circumscribed mass

Microscopic (histologic) description
  • Abundant, bizarre appearing tumor giant cells, many multinucleated; smaller fusiform cells, extensive necrosis, brisk mitotic activity, abundant stromal reticulin, occasional perivascular lymphocyte cuffing
Microscopic (histologic) images

Images hosted on PathOut server:

Case of Week #292: H&E and GFAP

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Bizarre giant cells

Giant cells and smaller fusiform cells

Staining vs. pleomorphic xanthoastrocytoma

Positive stains
Negative stains
  • Neuronal markers
Molecular / cytogenetics description
  • p53 mutations in 75 - 90%, PTEN mutations in 1/3; EGFR amplification is rare
Differential diagnosis
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