CNS tumor
Astrocytic tumors
Granular cell astrocytoma



Topic Completed: 1 March 2012

Revised: 16 May 2019

Revised: 2 January 2019, last major update March 2012

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PubMed Search: "Granular cell astrocytoma"


Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher E. Granular cell astrocytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorgranularcellastrocytic.html. Accessed August 24th, 2019.
Definition / general
Case reports
Microscopic (histologic) description
  • Prominent population of atypical granular cells (large, round with eosinophilic, PAS+ granules, eccentric nuclei), often with transition to a classic infiltrating glioma; often lymphocytic infiltrate or macrophages
Microscopic (histologic) images

Images hosted on other servers:

Neoplastic cells

Various stains

Positive stains
Electron microscopy description
  • Cytoplasmic granules are lysosomes, some autophagic
Differential diagnosis
  • Demyelinating disease
  • Histiocytic lesions
  • Infarctions
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