CNS tumor
Lymphoma and other hematopoietic lesions
Histiocytic lymphoma / sarcoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Histiocytic lymphoma / sarcoma CNS

Cite this page: Pernick, N. Histiocytic lymphoma / sarcoma. website. Accessed May 21st, 2018.
Definition / general
  • Very rare
  • Often fever, weight loss, hepatosplenomegaly and intestinal obstruction
Case reports
Microscopic (histologic) description
  • Large groups or sheets of large cells with abundant eosinophilic cytoplasm, pleomorphic vesicular nuclei, distinct nucleoli
  • Also necrosis, neutrophils (variable abscesses) and chronic inflammatory cells, hemophagocytosis
  • No infiltration of vascular walls
Positive stains
Negative stains
Electron microscopy description
  • Abundant cytoplasm with irregularly folded or multisegmented nuclei, lysosomes
  • No Birbeck granules, no interdigitating cell processes, no cell junctions
Molecular / cytogenetics description
  • No t(2;5)
  • Polyclonal
Differential diagnosis
  • Inflammatory processes
  • Other lymphomas and histiocytic neoplasms (use immunohistochemistry)
Additional references