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CNS tumor
Lymphoma and other hematopoietic lesions
Histiocytic lymphoma / sarcoma


Nat Pernick, M.D.

Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Histiocytic lymphoma / sarcoma CNS


Nat Pernick, M.D.
Page views in 2018: 369
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Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Positive stains | Negative stains | Electron microscopy description | Molecular / cytogenetics description | Differential diagnosis | Additional references
Cite this page: Pernick N. Histiocytic lymphoma / sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorhistiocyticsarcoma.html. Accessed December 5th, 2019.
Definition / general
  • Very rare
  • Often fever, weight loss, hepatosplenomegaly and intestinal obstruction
Case reports
Microscopic (histologic) description
  • Large groups or sheets of large cells with abundant eosinophilic cytoplasm, pleomorphic vesicular nuclei, distinct nucleoli
  • Also necrosis, neutrophils (variable abscesses) and chronic inflammatory cells, hemophagocytosis
  • No infiltration of vascular walls
Positive stains
Negative stains
Electron microscopy description
  • Abundant cytoplasm with irregularly folded or multisegmented nuclei, lysosomes
  • No Birbeck granules, no interdigitating cell processes, no cell junctions
Molecular / cytogenetics description
  • No t(2;5)
  • Polyclonal
Differential diagnosis
  • Inflammatory processes
  • Other lymphomas and histiocytic neoplasms (use immunohistochemistry)
Additional references
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