Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Positive stains | Negative stains | Electron microscopy description | Molecular / cytogenetics description | Differential diagnosis | Additional referencesCite this page: Pernick N. Histiocytic lymphoma / sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorhistiocyticsarcoma.html. Accessed December 5th, 2019.
Definition / general
- Very rare
- Often fever, weight loss, hepatosplenomegaly and intestinal obstruction
Case reports
- Histiocytic sarcoma involving the central nervous system (Am J Surg Pathol 2003;27:258)
Microscopic (histologic) description
- Large groups or sheets of large cells with abundant eosinophilic cytoplasm, pleomorphic vesicular nuclei, distinct nucleoli
- Also necrosis, neutrophils (variable abscesses) and chronic inflammatory cells, hemophagocytosis
- No infiltration of vascular walls
Negative stains
Electron microscopy description
- Abundant cytoplasm with irregularly folded or multisegmented nuclei, lysosomes
- No Birbeck granules, no interdigitating cell processes, no cell junctions
Molecular / cytogenetics description
- No t(2;5)
- Polyclonal
Differential diagnosis
- Inflammatory processes
- Other lymphomas and histiocytic neoplasms (use immunohistochemistry)
Additional references
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