CNS tumor
Lymphoma and other hematopoietic lesions
Lymphomatoid granulomatosis



Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

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PubMed Search: Lymphomatoid granulomatosis CNS


Nat Pernick, M.D.
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Cite this page: Pernick N. Lymphomatoid granulomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorlymphomatoidgranulomatosis.html. Accessed December 8th, 2019.
Definition / general
  • Lymphoproliferative disorder with features of inflammation, vasculitis and neoplasm; usually B cell disorder with reactive T cells
  • Has high rate of CNS involvement (20 - 50%), often associated with pulmonary disease
  • Rarely is isolated to CNS
  • May progress to lymphoma, particularly in AIDS patients
Microscopic (histologic) description
  • Angiocentric inflammation due to atypical lymphocytes with vessel wall destruction
  • Usually no well formed granulomas
Microscopic (histologic) images

Images hosted on other servers:

Perivascular lymphocytes, microglia and macrophages

Perivascular small lymphocytes with atypia

Positive stains
Additional references
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