CNS tumor
Neuronal and mixed neuronal - glial tumors
Malignant glioneuronal tumors

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 31 August 2017, last major update October 2013

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Malignant glioneuronal tumors

Cite this page: Abdelzaher, E. Malignant glioneuronal tumors. website. Accessed July 17th, 2018.
Definition / general
  • Rare poorly characterized heterogeneous group of mixed neuronal - glial tumors with anaplastic degeneration usually involving the glial component and less frequently the neuronal or both components
  • No consensus regarding classification or grading (Cancer 2008;113:3355)
  • Wide age range
Radiology images

Images hosted on other servers:

Irregular strong enhancing mass

Features of anaplastic gangliogliomas

Case reports
  • Surgery, radiotherapy, chemotherapy
Microscopic (histologic) description
  • Anaplastic ganglioglioma:
    • WHO grade III
    • Low grade neuronal component with ganglion / ganglioid cells
    • Anaplastic glial component
  • Anaplastic glioma with focal neuronal differentiation
    • Neuronal differentiation can be seen in a variety of anaplastic gliomas including:
      • Glioblastoma and giant cell glioblastoma
      • Glioneuronal tumour with neuropil-like islands
      • Pleomorphic xanthoastrocytoma with anaplastic features
    • Neuronal differentiation manifested as:
      • Ganglion and ganglioid cells or neurocytic differentiation
      • Neuropil islands / rosettes
      • PNET component (usually in glioblastoma)
      • Immunoexpression of neuronal markers
    • No prognostic significance except for PNET component
Microscopic (histologic) images

Images hosted on other servers:


Features suggestive of anaplastic gangliogliomas

Endothelial proliferations in ganglioglioma

Differential diagnosis
  • Infiltrating glioma with entrapped normal neurons