CNS tumor
Mesenchymal and other tumors

Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neurofibroma[title] central nervous system

Nat Pernick, M.D.
Page views in 2018: 868
Page views in 2019 to date: 732
Cite this page: Pernick N. Neurofibroma. website. Accessed December 6th, 2019.
Definition / general
  • Benign (grade I)
  • Arises within nerves and infiltrates them
  • Having multiple tumors or plexiform subtype is associated with neurofibromatosis 1
Case reports
Gross description
  • Fusiform enlargement of nerve from which it arises
Microscopic (histologic) description
  • Spindled Schwann cells with wire like collagen fibrils mixing with axons, stromal mucosubstances, mast cells, Wagner-Meissner corpuscles and fibroblasts
  • No Antoni A or B areas; vessels are thin walled without perivascular hemosiderin
Microscopic (histologic) images

Images hosted on other servers:

Collagen rich bundles in a loose matrix

Reticulin stain

Positive stains
Negative stains
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