CNS tumor
Mesenchymal and other tumors

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neurofibroma[title] central nervous system

Cite this page: Pernick, N. Neurofibroma. website. Accessed July 23rd, 2018.
Definition / general
  • Benign (grade I)
  • Arises within nerves and infiltrates them
  • Having multiple tumors or plexiform subtype is associated with neurofibromatosis 1
Case reports
Gross description
  • Fusiform enlargement of nerve from which it arises
Microscopic (histologic) description
  • Spindled Schwann cells with wire like collagen fibrils mixing with axons, stromal mucosubstances, mast cells, Wagner-Meissner corpuscles and fibroblasts
  • No Antoni A or B areas; vessels are thin walled without perivascular hemosiderin
Microscopic (histologic) images

Images hosted on other servers:

Collagen rich bundles in a loose matrix

Reticulin stain

Positive stains
Negative stains