CNS tumor
Pineal tumors
Papillary tumor of pineal region

Topic Completed: 01 January 2006

Revised: 2 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: "Papillary tumor of the pineal region"

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Cite this page: Pernick N. Papillary tumor of pineal region. website. Accessed January 21st, 2019.
Definition / general
  • First described in 2003 (Am J Surg Pathol 2003;27:505)
  • 4 of 6 were women, ages 19 - 53 years
  • May derive from ependymal cells of subcommissural organ (also chordoid glioma)
Radiology description
  • Well circumscribed pineal mass
Microscopic (histologic) description
  • Epithelial-like growth with vessels covered by a layer of tumor cells
  • Cells are large, columnar / cuboidal with clear cytoplasm, round or infolded nuclei at basal pole of tumor cells
  • May have rosettes
Positive stains
Negative stains
Electron microscopy description
  • Abundant rough endoplasmic reticulum with distended cisternae filled with secretory product
  • Also microvilli and perinuclear intermediate filaments
Differential diagnosis