Table of Contents
Definition / general | Radiology description | Microscopic (histologic) description | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Pernick N. Papillary tumor of pineal region. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorpapillarytumorpineal.html. Accessed March 28th, 2024.
Definition / general
- First described in 2003 (Am J Surg Pathol 2003;27:505)
- 4 of 6 were women, ages 19 - 53 years
- May derive from ependymal cells of subcommissural organ (also chordoid glioma)
Radiology description
- Well circumscribed pineal mass
Microscopic (histologic) description
- Epithelial-like growth with vessels covered by a layer of tumor cells
- Cells are large, columnar / cuboidal with clear cytoplasm, round or infolded nuclei at basal pole of tumor cells
- May have rosettes
Positive stains
Electron microscopy description
- Abundant rough endoplasmic reticulum with distended cisternae filled with secretory product
- Also microvilli and perinuclear intermediate filaments
Differential diagnosis
- Pineal parenchymal tumor: synaptophysin+, keratin-, vimentin-