CNS tumor
Astrocytic tumors
Pilomyxoid astrocytoma

Author: Eman Abdelzaher, M.D., Ph.D. (see Authors page)

Revised: 28 August 2017, last major update March 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pilomyxoid astrocytoma [title]

See also: Pilocytic astrocytoma - grade I
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Cite this page: Abdelzaher, E. Pilomyxoid astrocytoma. website. Accessed January 22nd, 2019.
Definition / general
  • Piloid neoplasm closely related to pilocytic astrocytoma with a prominent mucoid matrix and angiocentric arrangement of monomorphous bipolar cells
  • More aggressive than pilocytic astrocytoma with propensity to local recurrences and cerebrospinal spread
  • WHO grade II
  • Typically presents in very young (median 10 months)
  • No gender predilection
Radiology description
  • Circumscribed mass with homogenous contrast enhancement
  • Occasional CSF dissemination
Gross description
  • Solid gelatinous mass
Gross images

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Coronal sections through hypothalamus

Microscopic (histologic) description
  • Monomorphous intermediate sized bipolar cells in prominent mucoid matrix
  • Angiocentric cell arrangement is common
  • Typically no Rosenthal fibers, no eosinophilic granular bodies
Microscopic (histologic) images

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Monomorphous population of tumor cells

Positive stains