CNS tumor
Pineal tumors
Pineal parenchymal tumor of intermediate differentiation



Topic Completed: 1 January 2006

Revised: 2 January 2019, last major update January 2006

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PubMed Search: Pineal parenchymal tumor of intermediate differentiation


Nat Pernick, M.D.
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Cite this page: Pernick N. Pineal parenchymal tumor of intermediate differentiation. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorpinealparenchymalintermediate.html. Accessed October 19th, 2019.
Definition / general
  • Features intermediate between pineocytoma and pineoblastoma
  • 10% of pineal parenchymal tumors
  • Occasionally associated with CNS or extraneural metastasis but otherwise difficult to predict prognosis
  • Better survival than pineoblastoma
Microscopic (histologic) description
  • Marked hypercellularity but relatively bland nuclear features
  • No / mild nuclear pleomorphism
  • No / rare pinocytomatous rosettes
  • Minimal mitotic activity
Molecular / cytogenetics description
Additional references
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