CNS tumor
Tumors of the sellar region
Pituitary carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 September 2017, last major update January 2006

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Pituitary carcinoma [title]

Cite this page: Pernick, N. Pituitary carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorpituitarycarcinoma.html. Accessed October 18th, 2017.
Definition / general
  • 0.2 to 0.5% of adenohypophyseal tumors
  • Considered to derive from pituitary adenoma
  • Defined as tumors that have metastasized, since cannot differentiate based on histology (like other endocrine tumors)
  • Usually secrete ACTH or prolactin
  • "Silent" pituitary tumors rarely metastasize
  • Highly aggressive, eventually causing death
Case reports
Microscopic (histologic) description
  • May have nuclear pleomorphism with prominent nucleoli, mitotic activity
Positive stains
  • May have high Ki67 labeling index
  • p53
Differential diagnosis
Additional references