CNS tumor
CNS cysts
Rathke cleft cyst




Topic Completed: 1 February 2012

Revised: 31 December 2018, last major update February 2012

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PubMed Search: "Rathke cleft cyst"

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Cite this page: Abdelzaher E. Rathke cleft cyst. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cnstumorrathkecyst.html. Accessed February 19th, 2019.
Definition / general
  • Mucus containing cyst arising from Rathke cleft remnants
  • Intrasellar or suprasellar
  • Incidental postmortem finding
  • Larger cysts, usually in adults, may be symptomatic
Radiology images

Images hosted on other servers:

Various images

Gross description
  • Thin walled, mucinous contents
Microscopic (histologic) description
  • Lined by columnar ciliated epithelium with goblet cells
  • Variable fragments of pituitary tissue, squamous metaplasia, xanthogranulomatous reaction
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Differential diagnosis