CNS tumor
Mesenchymal and other tumors
Sarcoma (other than chondrosarcoma)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sarcoma[title] CNS

Cite this page: Pernick, N. Sarcoma (other than chondrosarcoma). website. Accessed May 21st, 2018.
Definition / general
  • Very rare ( < 1% of CNS tumors); more likely to be another tumor that is misdiagnosed
  • Usually cerebral but may be cerebellar or spinal cord
  • Median age 28 years, range 3 - 63 years
  • Often associated with prior radiation therapy (such as for craniopharyngioma or pituitary adenoma); these sarcomas cause rapid death from local invasion
  • Better prognosis if low grade but even high grade sarcomas have better survival than glioblastoma multiforme (Am J Surg Pathol 2002;26:1056)
  • References: fibrosarcoma (Neurol India 2000;48:396), Ewing sarcoma in CNS (Clin Neuropathol 2005;24:184, Acta Neurochir (Wien) 1991;113:48)
Case reports
Gross description
  • Median size 4 cm (1 - 8 cm)
Microscopic (histologic) description
  • Fibrosarcoma, MFH or undifferentiated subtypes are most common
  • Often high grade; no glial or meningothelial features
Microscopic (histologic) images

Images hosted on other servers:

Meningeal rhabdomyosarcoma: #2 with cross striations

Negative stains
Differential diagnosis