CNS tumor
Mesenchymal and other tumors
Solitary fibrous tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 12 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Solitary fibrous tumor CNS

Cite this page: Pernick, N. Solitary fibrous tumor. website. Accessed March 24th, 2018.
Definition / general
Case reports
Gross description
  • Smooth surface, no capsule; white tan, firm, slightly rubbery and compresses adjacent parenchyma
Gross images

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Tumor attached to dura

Microscopic (histologic) description
  • Haphazard (patternless) arrangement of monomorphic spindle cells with abundant ropy collagen mixed with tumor cells
  • May have alternating hypo and hypercellular areas with perivascular hyalinization or myxoid degeneration
  • Usually has hemangiopericytoma-like vascular pattern; no mitotic figures or necrosis
  • May have more aggressive behavior if hypercellular, pleomorphism, mitotic activity and necrosis (Brain Pathol 2001;11:485)
Microscopic (histologic) images

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H&E, CD34 and bcl2

Other stains

Various images from meningeal tumor

Tumor of hypoglossal nerve; #2: CD34+

Paraspinal tumor with frequent mitotic figures

Malignant tumor

Positive stains
Negative stains
Electron microscopy description
  • Resemble fibroblasts
Differential diagnosis
  • Fibrous meningioma: more common; cellular whorls and psammoma bodies, no dense collagenous bands, usually EMA+, S100+, weak / negative CD34 staining
  • Hemangiopericytoma: 80% recurrence rate, often causing death, has delicate prominent pericellular reticulin fibers, usually no dense collagen bands, focal CD34+
  • Schwannoma: alternating Antoni A and B areas, strongly S100+