CNS tumor
Tumors of the sellar region
Spindle cell oncocytoma of adenohypophysis

Topic Completed: 1 January 2006

Revised: 3 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Spindle cell oncocytoma of adenohypophysis

Nat Pernick, M.D.
Page views in 2019: 456
Page views in 2020 to date: 221
Cite this page: Pernick N. Spindle cell oncocytoma of adenohypophysis. website. Accessed May 26th, 2020.
Definition / general
  • First described in 2002 (Am J Surg Pathol 2002;26:1048)
  • Mean 62 years, range 53 - 71 years
  • Associated with panhypopituitarism and variable visual field defect
  • Benign; no recurrence if totally excised
  • May derive from adenohypophyseal folliculostellate cells
Radiology description
  • Suprasellar extension
  • Resembles pituitary adenoma
  • No dural involvement
Microscopic (histologic) description
  • Fascicles of spindle cells with granular and eosinophilic cytoplasm
  • No / rare mitotic figures
  • No necrosis
Positive stains
Negative stains
Electron microscopy description
  • Mitochodria rich in lamellar cristae
  • Intermediate junctions and desmosomes, rough endoplasmic reticulum
  • No secretory granules
Differential diagnosis
  • Ectopic salivary gland rests undergoing oncocytic transformation
  • Meningioma with oncocytic change: EMA+ but intrasellar extension is rare; also whorls, interdigitation of cell membrane, S100- (except in fibrous meningioma)
  • Metastatic extracranial oncocytic tumor
  • Pituitary adenoma with oncocytic change: keratin+, synpatophysin+, neurosecretory granules+; chromogranin+, S100-, vimentin-, EMA-
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