CNS tumor

Author: Nat Pernick, M.D. (see Authors page)

Revised: 12 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: TNM "staging" CNS tumor

Table of Contents
Definition / general
Cite this page: Pernick, N. Staging. website. Accessed July 17th, 2018.
Definition / general
  • No TNM classification exists for CNS tumors (Edge: AJCC Cancer Staging Manual, 7th Edition, 2010) for these reasons:
    • For T component, histology and location are more important than tumor size
    • For N component, brain and spinal cord have no lymphatics, so lymph nodes cannot be staged
    • For M component, most patients die before metastatic disease is identified (except for CSF seeding in some pediatric tumors)
    • Generally favorable prognostic factors: younger age, total resection vs. subtotal resection; higher Karnofsky performance scale