CNS tumor

Editorial Board Member: Maria Martinez-Lage, M.D.
Editor-in-Chief: Debra Zynger, M.D.
Nat Pernick, M.D.

Topic Completed: 1 September 2018

Revised: 3 January 2019, last major update September 2018

Copyright: (c) 2002-2018,, Inc.

PubMed Search: TNM "staging" CNS tumor

Nat Pernick, M.D.
Page views in 2019: 164
Page views in 2020 to date: 120
Table of Contents
Definition / general
Cite this page: Pernick N. Staging. website. Accessed June 1st, 2020.
Definition / general
  • No TNM classification exists for CNS tumors (Edge: AJCC Cancer Staging Manual, 8th Edition, 2017) for these reasons:
    • For T component, histology and location are more important than tumor size
    • For N component, brain and spinal cord tumors do not propagate in lymphatics, so lymph nodes are not staged
    • For M component, metastatic disease is rarely seen (except for CSF seeding in some pediatric tumors) and extremely rare outside of the CNS
    • WHO classification and WHO grading systems should be used
    • Generally favorable prognostic factors: younger age, total resection versus subtotal resection; higher Karnofsky performance scale
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