CNS tumor
Germ cell tumors
Yolk sac tumor

Topic Completed: 1 January 2006

Revised: 2 January 2019, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Yolk sac tumor CNS

Nat Pernick, M.D.
Page views in 2019: 399
Page views in 2020 to date: 233
Cite this page: Pernick N. Yolk sac tumor. website. Accessed May 26th, 2020.
Definition / general
  • Rare intracranial tumor, usually in pineal or suprasellar regions
  • Also called endodermal sinus tumor
  • Prognosis poorer than germinoma (median survival 2 years or less)
Case reports
Gross description
  • Usually large
Microscopic (histologic) description
  • Tubulopapillary structures with vacuolated cuboidal cells, cystic spaces with eosinophilic hyaline bodies and Schiller-Duval bodies
Microscopic (histologic) images

Images hosted on other servers:

Solid sheets of cells with clear to eosinophilic cytoplasm lacking fibrous septae

Papanicolaou stain

PAS with diastase pretreatment


AE1 / AE3

Positive stains
Additional references
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