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Coagulation
Acquired thrombophilia / hypercoagulopathies
Acquired thrombophilia-general

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 7 April 2013, last major update April 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Diagrams
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Initiation and propagation of blood coagulation
Activation of protein C by thrombin-thrombomodulin
Degradation of FVa and FVIIIa by APC
Blood coagulation and protein C anticoagulant system
Activation and degradation of normal FV and FV Leiden
20210G>A mutation in the prothrombin gene
Regulation of hemostasis
Balance of hemostasis
Genetic polymorphisms of various procoagulant proteins
Activated protein C (APC)
Transsulfuration pathway and metabolism of homocysteine
Case reports
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Clinical images
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Thrombi in major trunks of pulmonary artery and large thrombus near left iliac vein.
Micro images
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Fig. 1/2: old, recanalized thrombi in portal veins;
Fig. 3: recanalization of portal vein webs with intimal tags;
Fig. 4: bone marrow is hypercellular with large, dysplastic, abnormally clustered megakaryocytes
Additional references
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End of Coagulation > Acquired thrombophilia / hypercoagulopathies > Acquired thrombophilia-general


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