Coagulation - Acute phase reaction

Home Chapter Home Jobs Conferences Fellowships Books

Coagulation

Acquired bleeding disorders

Acute phase reaction

Reviewers: Kendall Crookston, M.D., Ph.D., University of New Mexico; Lizabeth Rosenbaum, MD, University of New Mexico; Julie Gober-Wilcox, M.D., Resident, University of New Mexico (see Reviewers page)
Revised: 8 October 2010, last major update September 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

Definition / General
=========================================================================

● Many serum proteins become elevated due to illness, injury, inflammation or stress; also pregnancy
● Elevated levels return to normal after condition resolves

Terminology
=========================================================================

● Also called positive acute phase proteins

Etiology
=========================================================================

● In response to injury, neutrophils and macrophages secrete IL-1, IL-6, IL-8 and TNF-a into the bloodstream; liver then produces acute-phase reactants (Wikipedia, COPE)
● Production of other proteins is reduced ("negative" acute phase reactants)

Laboratory
=========================================================================

● Associated with increase in fibrinogen, factor VIII, vWF (up to 3x normal levels) and PAI-1 (up to 50x)
● Associated with decrease in PTT, decrease in protein S (due to binding to increased C4b)

End of Coagulation > Acquired bleeding disorders > Acute phase reaction

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).