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Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Formerly called antithrombin III
● Member of serine protease inhibitor (serpin) gene family on #1q23-25
● Functions as anticoagulant by inhibiting activated factors II (thrombin), IX, X, XI, XII, kallikrein, plasmin and probably factor VII (all are serine proteases)
● Activity is accelerated 1000x by interaction with heparin or heparan sulfate (located on endothelial cells)


The body makes its own natural anticoagulants. Chart credit to Kendall Crookston, M.D., PhD.

Additional references

Arch Pathol Lab Med 2002;126:1326, Disorders of hemostasis & thrombosis: A clinical guide (2nd ed); 2000

End of Coagulation > General > Antithrombin

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