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Coagulation

General

Antithrombin

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Formerly called antithrombin III
● Member of serine protease inhibitor (serpin) gene family on #1q23-25
● Functions as anticoagulant by inhibiting activated factors II (thrombin), IX, X, XI, XII, kallikrein, plasmin and probably factor VII (all are serine proteases)
● Activity is accelerated 1000x by interaction with heparin or heparan sulfate (located on endothelial cells)

Diagrams
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The body makes its own natural anticoagulants. Chart credit to Kendall Crookston, M.D., PhD.

Additional references
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● Arch Pathol Lab Med 2002;126:1326, Disorders of hemostasis & thrombosis: A clinical guide (2nd ed); 2000

End of Coagulation > General > Antithrombin

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