Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Coagulation

General

Antithrombin


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Formerly called antithrombin III
● Member of serine protease inhibitor (serpin) gene family on #1q23-25
● Functions as anticoagulant by inhibiting activated factors II (thrombin), IX, X, XI, XII, kallikrein, plasmin and probably factor VII (all are serine proteases)
● Activity is accelerated 1000x by interaction with heparin or heparan sulfate (located on endothelial cells)

Diagrams
=========================================================================



The body makes its own natural anticoagulants. Chart credit to Kendall Crookston, M.D., PhD.

Additional references
=========================================================================

Arch Pathol Lab Med 2002;126:1326, Disorders of hemostasis & thrombosis: A clinical guide (2nd ed); 2000

End of Coagulation > General > Antithrombin


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).