Coagulation
General
Antithrombin

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 29 February 2016, last major update June 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Antithrombin [title] coagulation
Definition / General
  • Formerly called antithrombin III
  • Member of serine protease inhibitor (serpin) gene family on #1q23-25
  • Functions as anticoagulant by inhibiting activated factors II (thrombin), IX, X, XI, XII, kallikrein, plasmin and probably factor VII (all are serine proteases)
  • Activity is accelerated 1000x by interaction with heparin or heparan sulfate (located on endothelial cells)
Diagrams / Tables

Flickr image courtesy of Kendall Crookston, M.D., Ph.D.:

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Natural anticoagulants