Acquired bleeding disorders
Bovine coagulation factor inhibitors

Author: Kendall Crookston, M.D., Ph.D., Lizabeth Rosenbaum, M.D. and Julie Gober-Wilcox, M.D. (see Authors page)

Revised: 2 March 2016, last major update August 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Bovine coagulation factor inhibitors [title]
Cite this page: Bovine coagulation factor inhibitors. website. Accessed October 26th, 2016.
Definition / General
  • Antibodies that develop against bovine proteins after exposure to topical bovine thrombin preparations which can potentially cross-react with corresponding human coagulation factors
  • Antibodies can form against bovine thrombin, factor V/Va, and fibrinogen, and less commonly against bovine factors VII and X
  • Some fibrin glues contain bovine thrombin and cryoprecipitate (containing human fibrinogen)
  • After use of bovine "fibrin glue" to achieve hemostasis, 1.7% develop a clinically significant inhibitor
  • Prolonged PT and PTT that does not correct with mixing studies
Case Reports
  • Steroids, cyclophosphamide, cyclosporine A, IV immunoglobulin
  • Management of acute bleeding includes plasmapheresis, platelet-transfusions and immunoabsorption