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Coagulation
Acquired bleeding disorders
Bovine coagulation factor inhibitors

Kendall Crookston, M.D., Ph.D.
Lizabeth S. Rosenbaum, M.D.

Topic Completed: 1 August 2010

Revised: 4 January 2019, last major update August 2010

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PubMed Search: Bovine coagulation factor inhibitors [title]

Kendall Crookston, M.D., Ph.D.
Lizabeth S. Rosenbaum, M.D.
Page views in 2018: 19
Page views in 2019 to date: 17
Table of Contents
Definition / general | Laboratory | Case reports | Treatment | Differential diagnosis
Cite this page: Crookston K., Rosenbaum L., Gober-Wilcox J. Bovine coagulation factor inhibitors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationbovinecoagulationfactor.html. Accessed December 9th, 2019.
Definition / general
  • Antibodies that develop against bovine proteins after exposure to topical bovine thrombin preparations which can potentially cross-react with corresponding human coagulation factors
  • Antibodies can form against bovine thrombin, factor V/Va, and fibrinogen, and less commonly against bovine factors VII and X
  • Some fibrin glues contain bovine thrombin and cryoprecipitate (containing human fibrinogen)
  • After use of bovine "fibrin glue" to achieve hemostasis, 1.7% develop a clinically significant inhibitor
Laboratory
  • Prolonged PT and PTT that does not correct with mixing studies
Case reports
Treatment
  • Steroids, cyclophosphamide, cyclosporine A, IV immunoglobulin
  • Management of acute bleeding includes plasmapheresis, platelet-transfusions and immunoabsorption
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