Coagulation
Acquired bleeding disorders
Bovine coagulation factor inhibitors
Topic Completed: 1 August 2010
Revised: 4 January 2019, last major update August 2010
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PubMed Search: Bovine coagulation factor inhibitors [title]
Table of Contents
Definition / general | Laboratory | Case reports | Treatment | Differential diagnosisCite this page: Crookston K., Rosenbaum L., Gober-Wilcox J. Bovine coagulation factor inhibitors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationbovinecoagulationfactor.html. Accessed August 7th, 2020.
Definition / general
- Antibodies that develop against bovine proteins after exposure to topical bovine thrombin preparations which can potentially cross-react with corresponding human coagulation factors
- Antibodies can form against bovine thrombin, factor V/Va, and fibrinogen, and less commonly against bovine factors VII and X
- Some fibrin glues contain bovine thrombin and cryoprecipitate (containing human fibrinogen)
- After use of bovine "fibrin glue" to achieve hemostasis, 1.7% develop a clinically significant inhibitor
Laboratory
- Prolonged PT and PTT that does not correct with mixing studies
Case reports
- Case reports of 2 children who developed anti-factor V antibodies following bovine thrombin exposure (Pediatr Blood Cancer 2007;49:1025)
Treatment
- Steroids, cyclophosphamide, cyclosporine A, IV immunoglobulin
- Management of acute bleeding includes plasmapheresis, platelet-transfusions and immunoabsorption
Differential diagnosis
