Acquired bleeding disorders
Bovine coagulation factor inhibitors

Topic Completed: 1 August 2010

Revised: 4 January 2019, last major update August 2010

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Bovine coagulation factor inhibitors [title]

Kendall Crookston, M.D., Ph.D.
Lizabeth S. Rosenbaum, M.D.
Page views in 2019: 17
Page views in 2020 to date: 7
Cite this page: Crookston K., Rosenbaum L., Gober-Wilcox J. Bovine coagulation factor inhibitors. website. Accessed August 7th, 2020.
Definition / general
  • Antibodies that develop against bovine proteins after exposure to topical bovine thrombin preparations which can potentially cross-react with corresponding human coagulation factors
  • Antibodies can form against bovine thrombin, factor V/Va, and fibrinogen, and less commonly against bovine factors VII and X
  • Some fibrin glues contain bovine thrombin and cryoprecipitate (containing human fibrinogen)
  • After use of bovine "fibrin glue" to achieve hemostasis, 1.7% develop a clinically significant inhibitor
  • Prolonged PT and PTT that does not correct with mixing studies
Case reports
  • Steroids, cyclophosphamide, cyclosporine A, IV immunoglobulin
  • Management of acute bleeding includes plasmapheresis, platelet-transfusions and immunoabsorption
Back to top