Common pathway

Author: Jeremey Parsons, M.D. (see Authors page)

Revised: 29 February 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Common pathway [title] coagulation
Cite this page: Common pathway. website. Accessed September 22nd, 2018.
Definition / general
  • Involves fibrinogen (factor I), factors II (prothrombin), V, X
  • Thrombin converts soluble fibrinogen to insoluble fibrin
    • Releases fibrinopeptides A and B
  • Remaining fibrin monomers polymerize to form fibrin
  • Thrombin also binds to antithrombin, which inhibits thrombin to prevent excessive clotting
  • Thrombin may also activate factor XI (part of intrinsic pathway), factors V, VIII, XIII, XI and platelets
  • Factor XIII cross links fibrin to increase stability of fibrin clot
  • While both PT and aPTT include the common pathway, the PT is a more sensitive screening test for common pathway problems
Diagrams / tables

Images hosted on Other server:

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Flickr images courtesy of Kendall Crookston, M.D., Ph.D.:

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Intrinsic, common, and extrinsic pathways

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In vivo coagulation cascade