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Coagulation
General
Common pathway
Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
General
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● Involves fibrinogen (factor I), factors II (prothrombin), V, X
● Thrombin converts soluble fibrinogen to insoluble fibrin; releases fibrinopeptides A and B
● Remaining fibrin monomers polymerize to form fibrin
● Thrombin also binds to antithrombin, which inhibits thrombin to prevent excessive clotting
● Thrombin may also activate factor XI (part of intrinsic pathway), factors V, VIII, XIII, XI and platelets
● Factor XIII cross links fibrin to increase stability of fibrin clot
● While both PT and aPTT include the common pathway, the PT is a more sensitive screening test for common pathway problems
Diagrams
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Additional references
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● M Blomback, J Antovic (Eds), Essential Guide to Blood Coagulation 2010; Wiley-Blackwell: pages 13-18
End of Coagulation > General > Common pathway
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