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Coagulation

Therapy related coagulopathies

Danaparoid (Orgaran)


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 12 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Approved to prevent deep venous thromboses
● Also an alternative to heparin for patients with heparin induced thrombocytopenia (Crit Care 2007;11:R102)
● Use is decreasing due to newer anticoagulants
● Composed of low molecular weight glycosaminoglycans (mixture of heparan sulfate, dermatan sulfate and chondroitin sulfate) that primarily inhibit factor Xa, factor IIa to a much lesser extent

Clinical features
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● Similar to low molecular weight heparin in having a more predictable anticoagulant effect, with less need for laboratory monitoring
● Monitor, if desired, by measuring inhibitor of factor Xa using standard curve; draw 6 hours after subcutaneous injection; PT and PTT are unaffected
● Therapeutic levels to treat DVT are 0.5-0.8 anti-factor Xa units/ml, lower for DVT prophylaxis
● Long half-life, is prolonged with renal failure
● No reversal agent is known, but incomplete reversal is shown with protamine sulfate
● Not marketed in the US since 2004, still available in some countries.

End of Coagulation > Therapy related coagulopathies > Danaparoid (Orgaran)


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