Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Coagulation laboratory tests

Ecarin clotting time

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 20 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Measures activity of hirudin in plasma, important since severe bleeding can occur with hirudin overdose and no antidote is known
● Also measures activity of lepirudin, a recombinant form of hirudin (J Extra Corpor Technol 2001;33:117)
● Ecarin catalyzes prothrombin to meizothrombin, an active form that is inhibited by hirudin (Pathophysiol Haemost Thromb 2004;33:173)
● Test measures ability of hirudin to complex with / inhibit meizothrombin as ecarin produces it from prothrombin
● Ecarin comes from the venon of the saw-scaled viper

● Sodium citrate tube filled to top
● Freeze immediately until testing occurs
● Specimens with clots or hemolysis are unacceptable, unless hemolysis is due to cardiopulmonary bypass and is produced in vivo
● Do not draw from heparinized catheter

Reference range:
● 22.6 to 29.0 seconds
● Prolonged if hirudin or argatroban (direct thrombin inhibitors) present; also hypofibrinogenemia, dysfibrinogenemia
● False positive if prothrombin deficiency is present

End of Coagulation > Coagulation laboratory tests > Ecarin clotting time

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).