Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Coagulation

Coagulation laboratory tests

Factor VIII assay


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 21 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Assay is usually a PTT-based clotting assay that measures factor VIII activity
● Use severely deficient factor VIII plasma as substrate for one stage clotting assay, although there is tremendous interlaboratory variability
● Can also use chromogenic assay, particularly when assessing B-chain deleted recombinant Factor VIII (i.e. “Refacto”)

Low levels:
● Hemophilia, vWF disease with decreased vWF antigen levels, delay in transporting specimen to lab

Note:
● Levels are not greatly decreased at birth or throughout childhood
● Levels may increase during pregnancy

Additional references
=========================================================================

Kessler, C. (2007). Hemorrhagic disorders: Coagulation factor deficiencies. In L. Goldman, D. Ausiello (Eds.), Cecil Medicine (pp.1301-1313). Philadelphia, PA: Saunders Elsevier.

End of Coagulation > Coagulation laboratory tests > Factor VIII assay


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).