Coagulation
Coagulation laboratory tests
Hypercoagulation panel



Topic Completed: 1 November 2012

Revised: 7 January 2019, last major update November 2012

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PubMed Search: Hypercoagulation panel


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Table of Contents
Definition / general
Cite this page: Parsons J. Hypercoagulation panel. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationhypercoagulationpanel.html. Accessed October 21st, 2019.
Definition / general
  • Panels are useful to identify all factors predisposing to thrombosis; vary by institution
  • Laboratory must be notified if patient is receiving therapeutic anticoagulants (heparin, warfarin, danaparoid, hirudin, argatroban)
  • Venous thrombosis panel typically includes assays for activated protein C resistance (factor V Leiden), protein C, protein S, antithrombin, prothrombin G20210A mutation assay, antiphospholipid antibodies and homocysteine
  • Less common are assays for plasminogen, dysfibrinogenemia (e.g. reptilase time), heparin cofactor II or platelet hyperaggregability
  • Arterial thrombosis panel may include antiphospholipid antibodies, homocysteine levels, lipoprotein (a) (if arterial thrombosis occurs with coronary artery disease, myocardial infarction or stroke)
  • In special circumstances, arterial thrombosis may be due to thrombotic diatheses tested on the venous thrombosis panel

  • Note: clinicians often confuse Factor V Leiden (to workup thrombosis) with Factor V assay (not the correct test); prevent with use of hypercoagulation panel
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