Coagulation laboratory tests
Hypercoagulation panel

Topic Completed: 1 November 2012

Revised: 7 January 2019, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Hypercoagulation panel

Page views in 2019: 136
Page views in 2020 to date: 64
Table of Contents
Definition / general
Cite this page: Parsons J. Hypercoagulation panel. website. Accessed June 4th, 2020.
Definition / general
  • Panels are useful to identify all factors predisposing to thrombosis; vary by institution
  • Laboratory must be notified if patient is receiving therapeutic anticoagulants (heparin, warfarin, danaparoid, hirudin, argatroban)
  • Venous thrombosis panel typically includes assays for activated protein C resistance (factor V Leiden), protein C, protein S, antithrombin, prothrombin G20210A mutation assay, antiphospholipid antibodies and homocysteine
  • Less common are assays for plasminogen, dysfibrinogenemia (e.g. reptilase time), heparin cofactor II or platelet hyperaggregability
  • Arterial thrombosis panel may include antiphospholipid antibodies, homocysteine levels, lipoprotein (a) (if arterial thrombosis occurs with coronary artery disease, myocardial infarction or stroke)
  • In special circumstances, arterial thrombosis may be due to thrombotic diatheses tested on the venous thrombosis panel

  • Note: clinicians often confuse Factor V Leiden (to workup thrombosis) with Factor V assay (not the correct test); prevent with use of hypercoagulation panel
Back to top