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Coagulation laboratory tests

Hypercoagulation panel

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 10 January 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Panels are useful to identify all factors predisposing to thrombosis; vary by institution
● Laboratory must be notified if patient is receiving therapeutic anticoagulants (heparin, warfarin, danaparoid, hirudin, argatroban)
● Venous thrombosis panel typically includes assays for activated protein C resistance (factor V Leiden), protein C, protein S, antithrombin, prothrombin G20210A mutation assay, antiphospholipid antibodies and homocysteine
● Less common are assays for plasminogen, dysfibrinogenemia (e.g. reptilase time), heparin cofactor II or platelet hyperaggregability
● Arterial thrombosis panel may include antiphospholipid antibodies, homocysteine levels, lipoprotein (a) [if arterial thrombosis occurs with coronary artery disease, myocardial infarction or stroke]
● In special circumstances, arterial thrombosis may be due to thrombotic diatheses tested on the venous thrombosis panel
● Note: clinicians often confuse Factor V Leiden (to workup thrombosis) with Factor V assay (not the correct test); prevent with use of hypercoagulation panel

End of Coagulation > Coagulation laboratory tests > Hypercoagulation panel

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