Acquired bleeding disorders
Liver dysfunction

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 March 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Liver dysfunction [title] coagulation
Table of Contents
Definition / general
Cite this page: Liver dysfunction. website. Accessed July 18th, 2018.
Definition / general
  • Liver is site of production of most coagulation factors, but response of each factor to liver disease is variable due to differences in biologic half lives and acute phase reactions
  • PT usually prolonged first, then PTT
  • Factor VII: shortest biologic half life, often affected earliest with largest decrease in serum level
    • Factor VII also decreases earliest with warfarin treatment
  • Factor VIII: may be normal or elevated due to acute phase reaction
  • Factors XI and XII: long biologic half lives, may be normal until liver disease is advanced