Acquired bleeding disorders
Liver dysfunction

Topic Completed: 1 June 2012

Revised: 4 January 2019, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Liver dysfunction [title] coagulation

Nat Pernick, M.D.
Page views in 2019: 47
Page views in 2020 to date: 18
Table of Contents
Definition / general
Cite this page: Pernick N. Liver dysfunction. website. Accessed July 4th, 2020.
Definition / general
  • Liver is site of production of most coagulation factors, but response of each factor to liver disease is variable due to differences in biologic half lives and acute phase reactions
  • PT usually prolonged first, then PTT
  • Factor VII: shortest biologic half life, often affected earliest with largest decrease in serum level
    • Factor VII also decreases earliest with warfarin treatment
  • Factor VIII: may be normal or elevated due to acute phase reaction
  • Factors XI and XII: long biologic half lives, may be normal until liver disease is advanced
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