Acquired bleeding disorders
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 23 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
● Liver is site of production of most coagulation factors, but response of each factor to liver disease is variable due to differences in biologic half lives and acute phase reactions
● PT usually prolonged first, then PTT
● Factor VII: shortest biologic half life, often affected earliest with largest decrease in serum level; Factor VII also decreases earliest with warfarin treatment
● Factor VIII: may be normal or elevated due to acute phase reaction
● Factors XI and XII: long biologic half lives, may be normal until liver disease is advanced
End of Coagulation > Acquired bleeding disorders > Liver dysfunction
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