Normal hemostasis

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 29 February 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Normal hemostasis [title]
Cite this page: Normal hemostasis. website. Accessed June 20th, 2018.
Definition / general
  • Primary hemostasis: initial step of forming platelet plug to stop bleeding from damaged vessel
  • Secondary hemostasis: platelet plug is reinforced by fibrin clot
    • Then fibrin clot is stabilized by activated factor XIII, which cross-links fibrin strands
  • Tertiary hemostasis: as fibrin clot is formed, plasmin is generated to break down the clot
  • Fibrin clot may occur via intrinsic or extrinsic pathway or both; in vivo it occurs via a hybrid model
Diagrams / tables

Images hosted on Other server:

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Flickr images courtesy of Kendall Crookston, M.D., Ph.D.:

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Intrinsic, common, and extrinsic pathways

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In vivo coagulation cascade