Normal hemostasis

Topic Completed: 1 June 2012

Revised: 4 January 2019, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Normal hemostasis [title]

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Cite this page: Parsons J. Normal hemostasis. website. Accessed January 26th, 2020.
Definition / general
  • Primary hemostasis: initial step of forming platelet plug to stop bleeding from damaged vessel
  • Secondary hemostasis: platelet plug is reinforced by fibrin clot
    • Then fibrin clot is stabilized by activated factor XIII, which cross-links fibrin strands
  • Tertiary hemostasis: as fibrin clot is formed, plasmin is generated to break down the clot
  • Fibrin clot may occur via intrinsic or extrinsic pathway or both; in vivo it occurs via a hybrid model
Diagrams / tables

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Intrinsic, common, and extrinsic pathways

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In vivo coagulation cascade

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