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Coagulation

Coagulation laboratory tests

Platelet hyperaggregation studies

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 10 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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● Hyperaggregation may rarely be associated with hypercoagulability, including myocardial infarction, strokes and venous thrombosis
● Tested patients should have abstained from aspirin, NSAIDs or platelet-inhibiting drugs for 7 days prior to testing
● Indications: patients with unexplained hypercoagulability and normal values in hypercoagulation panel

Methodology
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● Similar to platelet aggregation
● Centrifuge citrated plasma gently to draw red and white blood cells into a pellet, which leaves platelets suspended in the plasma
● Then add various agonists at multiple low concentrations and a control (no agonist, to measure spontaneous aggregation), and measure platelet aggregation with an aggregometer (which measures optical density)
● Must carefully evaluate patient’s use of medications (including over the counter)
● Must compare to normal control, and results can be subjective

Additional references
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● Semin Thromb Hemost 1999;25:361, The Laboratory Test Handbook 2001:327

End of Coagulation > Coagulation laboratory tests > Platelet hyperaggregation studies

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