Coagulation
Coagulation laboratory tests
Platelet hyperaggregation studies

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 17 May 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Platelet hyperaggregation studies

Cite this page: Platelet hyperaggregation studies. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationplatelethyperaggregationstudies.html. Accessed December 7th, 2016.
Definition / General
  • Hyperaggregation may rarely be associated with hypercoagulability, including myocardial infarction, strokes and venous thrombosis
  • Tested patients should have abstained from aspirin, NSAIDs or platelet-inhibiting drugs for 7 days prior to testing

  • Indications: patients with unexplained hypercoagulability and normal values in hypercoagulation panel
Laboratory
  • Similar to platelet aggregation
  • Centrifuge citrated plasma gently to draw red and white blood cells into a pellet, which leaves platelets suspended in the plasma
  • Then add various agonists at multiple low concentrations and a control (no agonist, to measure spontaneous aggregation), and measure platelet aggregation with an aggregometer (which measures optical density)
  • Must carefully evaluate patient's use of medications (including over the counter)
  • Must compare to normal control, and results can be subjective