Coagulation laboratory tests
Platelet hyperaggregation studies

Topic Completed: 1 November 2012

Revised: 7 January 2019, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Platelet hyperaggregation studies

Page views in 2019: 518
Page views in 2020 to date: 198
Cite this page: Parsons J. Platelet hyperaggregation studies. website. Accessed July 10th, 2020.
Definition / general
  • Hyperaggregation may rarely be associated with hypercoagulability, including myocardial infarction, strokes and venous thrombosis
  • Tested patients should have abstained from aspirin, NSAIDs or platelet-inhibiting drugs for 7 days prior to testing

  • Indications: patients with unexplained hypercoagulability and normal values in hypercoagulation panel
  • Similar to platelet aggregation
  • Centrifuge citrated plasma gently to draw red and white blood cells into a pellet, which leaves platelets suspended in the plasma
  • Then add various agonists at multiple low concentrations and a control (no agonist, to measure spontaneous aggregation), and measure platelet aggregation with an aggregometer (which measures optical density)
  • Must carefully evaluate patient's use of medications (including over the counter)
  • Must compare to normal control, and results can be subjective
Back to top