Coagulation laboratory tests
Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
● Clotting time similar to thrombin time, but uses snake venom (Reptilase) instead of thrombin
● Measure rate of fibrin clot formation after addition of reptilase to citrated plasma
● Generates a fibrin clot by cleaving fibrinopeptide A from fibrinogen
● Prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products; also amyloidosis (inhibits fibrinogen conversion to fibrin); also prolonged by increased fibrinogen associated with acute phase reaction (Am J Clin Pathol 2002;118:263)
● Used to diagnose dysfibrinogenemia (also thrombin time)
● Not prolonged by heparin or hirudin (unlike thrombin time)
End of Coagulation > Coagulation laboratory tests > Reptilase time
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