Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Coagulation laboratory tests

Reptilase time

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Clotting time similar to thrombin time, but uses snake venom (Reptilase) instead of thrombin
● Measure rate of fibrin clot formation after addition of reptilase to citrated plasma
● Generates a fibrin clot by cleaving fibrinopeptide A from fibrinogen
● Prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products; also amyloidosis (inhibits fibrinogen conversion to fibrin); also prolonged by increased fibrinogen associated with acute phase reaction (Am J Clin Pathol 2002;118:263)
● Used to diagnose dysfibrinogenemia (also thrombin time)
● Not prolonged by heparin or hirudin (unlike thrombin time)

End of Coagulation > Coagulation laboratory tests > Reptilase time

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).