Hereditary thrombophilia / hypercoagulopathies
Sickle cell disease

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 2 May 2016, last major update June 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: Sickle cell disease [title]

Cite this page: Sickle cell disease. website. Accessed September 22nd, 2018.
Definition / general
  • Associated with increases in thrombin generation, fibrinolytic activation, platelet activation, increased antiphospholipid antibodies, decreased levels of circulating anticoagulants and contact factors
  • Also increased circulating levels of tissue factor and endothelial cells expressing a tissue factor phenotype
  • Have hypercoagulable state based on thermoelastographic profiles (Arch Pathol Lab Med 2005;129:760)
Additional references