Cite this page: Sickle cell disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationsicklecelldisease.html. Accessed February 22nd, 2018.
Definition / general
- Associated with increases in thrombin generation, fibrinolytic activation, platelet activation, increased antiphospholipid antibodies, decreased levels of circulating anticoagulants and contact factors
- Also increased circulating levels of tissue factor and endothelial cells expressing a tissue factor phenotype
- Have hypercoagulable state based on thermoelastographic profiles (Arch Pathol Lab Med 2005;129:760)