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Hereditary thrombophilia / hypercoagulopathies

Sickle cell disease

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 20 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Associated with increases in thrombin generation, fibrinolytic activation, platelet activation, increased antiphospholipid antibodies, decreased levels of circulating anticoagulants and contact factors
● Also increased circulating levels of tissue factor and endothelial cells expressing a tissue factor phenotype
● Have hypercoagulable state based on thermoelastographic profiles (Arch Pathol Lab Med 2005;129:760)

Additional references

J Clin Pathol 1980;33:622

End of Coagulation > Hereditary thrombophilia / hypercoagulopathies > Sickle cell disease

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