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Coagulation

Coagulation laboratory tests

tPA


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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● tPA activity / antigen and PAI-1 activity / antigen are used to evaluate fibrinolysis; often PAI-1 activity and tPA antigen are ordered together
● PAI-1 rapidly forms a complex with free tPA in the specimen
● Not recommended for routine clinical laboratories due to complexity and special handling requirements
● Can also measure tPA plasma concentration by ELISA or other immunologic assays
● Resting level is usually low, not clinically significant
● Post-stimulation level (such as after venous occlusion for 10 minutes) may be more useful
● Higher levels in patients with acute paraquat intoxication (J Korean Med Sci 2011;26:474)

Methodology
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● Must first inhibit interaction of tPA with PAI1 (its functional inhibitor) by acidifying plasma
● Determine activity by measuring plasmin activity from conversion of plasminogen

End of Coagulation > Coagulation laboratory tests > tPA


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