Coagulation laboratory tests
Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
● tPA activity / antigen and PAI-1 activity / antigen are used to evaluate fibrinolysis; often PAI-1 activity and tPA antigen are ordered together
● PAI-1 rapidly forms a complex with free tPA in the specimen
● Not recommended for routine clinical laboratories due to complexity and special handling requirements
● Can also measure tPA plasma concentration by ELISA or other immunologic assays
● Resting level is usually low, not clinically significant
● Post-stimulation level (such as after venous occlusion for 10 minutes) may be more useful
● Higher levels in patients with acute paraquat intoxication (J Korean Med Sci 2011;26:474)
● Must first inhibit interaction of tPA with PAI1 (its functional inhibitor) by acidifying plasma
● Determine activity by measuring plasmin activity from conversion of plasminogen
End of Coagulation > Coagulation laboratory tests > tPA
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).