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Coagulation laboratory tests

Thrombin time

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Measures rate of fibrin clot formation after addition of standard concentration of thrombin to citrated plasma (Practical Hemostasis and Thrombosis 2009:53)
● Thrombin cleaves fibrinogen, releasing fibrinopeptides A and B, converting fibrinogen to fibrin
● Useful to diagnose dysfibrinogenemia after more common disorders are excluded
Reference range: 10-13 or 16-24 seconds, depending on reaction conditions and thrombin concentration
● Prolonged if even small amounts of heparin, hirudin or argatroban anticoagulants are present
● Also prolonged with dysfibrinogenemia, amyloidosis (inhibits fibrinogen conversion to fibrin), DIC, thrombolytic therapy or thrombin inhibitors in patients exposed to bovine thrombin

End of Coagulation > Coagulation laboratory tests > Thrombin time

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