Coagulation laboratory tests
Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
● Measures rate of fibrin clot formation after addition of standard concentration of thrombin to citrated plasma (Practical Hemostasis and Thrombosis 2009:53)
● Thrombin cleaves fibrinogen, releasing fibrinopeptides A and B, converting fibrinogen to fibrin
● Useful to diagnose dysfibrinogenemia after more common disorders are excluded
● Reference range: 10-13 or 16-24 seconds, depending on reaction conditions and thrombin concentration
● Prolonged if even small amounts of heparin, hirudin or argatroban anticoagulants are present
● Also prolonged with dysfibrinogenemia, amyloidosis (inhibits fibrinogen conversion to fibrin), DIC, thrombolytic therapy or thrombin inhibitors in patients exposed to bovine thrombin
End of Coagulation > Coagulation laboratory tests > Thrombin time
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).