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Coagulation

General

Thrombomodulin


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 7 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● Intrinsic membrane glycoprotein on luminal surface of endothelial cells that binds thrombin and facilitates the activation of protein C
● C/T dimorphism at nucleotide 1418 is associated with premature myocardial infarction, but no definite association with venous thromboembolism
● See also discussion in Stains chapter

Diagrams
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Thrombomodulin / Protein C relationships and function


Thrombomodulin protein

Additional references
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BMC Neurology 2004;4:21

End of Coagulation > General > Thrombomodulin


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