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Coagulation

Coagulation laboratory tests

von Willebrand factor antigen assay (vWF)


Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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● Levels can increase 2-3x with injury, infection or other acute phase reactant stimulus (30% level at baseline can increase to 90% by the time the patient is tested); can determine presence of acute phase reaction by measuring fibrinogen
● Reference range is higher in children < 6 months old than adults (abnormal value in 3 month old may be normal for an adult)
● Minor injuries may produce major bleeds in children, leading to false accusations of child abuse
● Type O patients have significantly lower vWF antigen levels (75%) compared to type A (106%), type B (117%) and type AB (123%); although bleeding symptoms may depend on vWF antigen levels, regardless of ABO type
● Used to determine if patient with personal or family history of bleeding has von Willebrand disease; also to assist in determining hemophilia A carrier status in females

Methodology
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● ELISA assay measures quantity of vWF, not function (Can J Vet Res 2008;72:420)
● Can also use latex particles coated with anti-vWF antibodies, measure light absorbance; rocket immunoelectrophoresis

End of Coagulation > Coagulation laboratory tests > von Willebrand factor antigen assay (vWF)


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