Coagulation
Coagulation laboratory tests
von Willebrand factor antigen assay

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 18 May 2016, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Coagulation laboratory tests AND von Willebrand factor antigen assay

Table of Contents
Definition / General | Laboratory
Cite this page: von Willebrand factor antigen assay. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationvWF.html. Accessed December 7th, 2016.
Definition / General
  • Levels can increase 2 - 3x with injury, infection or other acute phase reactant stimulus (30% level at baseline can increase to 90% by the time the patient is tested); can determine presence of acute phase reaction by measuring fibrinogen
  • Reference range is higher in children < 6 months old than adults (abnormal value in 3 month old may be normal for an adult)
  • Minor injuries may produce major bleeds in children, leading to false accusations of child abuse
  • Type O patients have significantly lower vWF antigen levels (75%) compared to type A (106%), type B (117%) and type AB (123%); although bleeding symptoms may depend on vWF antigen levels, regardless of ABO type
  • Used to determine if patient with personal or family history of bleeding has von Willebrand disease; also to assist in determining hemophilia A carrier status in females
Laboratory
  • ELISA assay measures quantity of vWF, not function (Can J Vet Res 2008;72:420)
  • Can also use latex particles coated with anti-vWF antibodies, measure light absorbance; rocket immunoelectrophoresis