Coagulation
Coagulation laboratory tests
von Willebrand factor multimer analysis

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 18 May 2016, last major update November 2012

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PubMed Search: von Willebrand factor multimer analysis

Table of Contents
Definition / General
Cite this page: von Willebrand factor multimer analysis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationvWFmultimers.html. Accessed December 4th, 2016.
Definition / General
  • To detect type 2 von Willebrand disease
  • Involves separation of multimers by size using agarose gel electrophoresis of patients plasma (Thromb Res 2010;126:543)
  • Then detect multimers using radiolabeled or enzyme linked anti-vWF antibody
  • Normal in von Willebrands disease types 1, 2N or 2M (type 1 has reduced quantity of all sizes, but difficult to identify on gel)
  • No / reduced high molecular weight multimers in types 2A and 2B von Willebrands disease
  • No / reduced intermediate molecular weight multiples in type 2A
  • No / marked reduction in all multimers in type 3