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Coagulation

Coagulation laboratory tests

von Willebrand factor multimer analysis

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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● To detect type 2 von Willebrand disease
● Involves separation of multimers by size using agarose gel electrophoresis of patient’s plasma (Thromb Res 2010;126:543)
● Then detect multimers using radiolabeled or enzyme linked anti-vWF antibody
● Normal in von Willebrand’s disease types 1, 2N or 2M (type 1 has reduced quantity of all sizes, but difficult to identify on gel)
● No / reduced high molecular weight multimers in types 2A and 2B von Willebrand’s disease
● No / reduced intermediate molecular weight multiples in type 2A
● No / marked reduction in all multimers in type 3

End of Coagulation > Coagulation laboratory tests > von Willebrand factor multimer analysis

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