Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Coagulation laboratory tests

von Willebrand factor multimer analysis

Reviewer: Jeremy Parsons, M.D. (see Reviewers page)
Revised: 11 February 2013, last major update November 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● To detect type 2 von Willebrand disease
● Involves separation of multimers by size using agarose gel electrophoresis of patientís plasma (Thromb Res 2010;126:543)
● Then detect multimers using radiolabeled or enzyme linked anti-vWF antibody
● Normal in von Willebrandís disease types 1, 2N or 2M (type 1 has reduced quantity of all sizes, but difficult to identify on gel)
● No / reduced high molecular weight multimers in types 2A and 2B von Willebrandís disease
● No / reduced intermediate molecular weight multiples in type 2A
● No / marked reduction in all multimers in type 3

End of Coagulation > Coagulation laboratory tests > von Willebrand factor multimer analysis

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).