Coagulation laboratory tests
von Willebrand factor multimer analysis

Author: Jeremy Parsons, M.D. (see Authors page)

Revised: 18 May 2016, last major update November 2012

Copyright: (c) 2002-2016,, Inc.

PubMed Search: von Willebrand factor multimer analysis

Table of Contents
Definition / general
Cite this page: von Willebrand factor multimer analysis. website. Accessed April 27th, 2018.
Definition / general
  • To detect type 2 von Willebrand disease
  • Involves separation of multimers by size using agarose gel electrophoresis of patients plasma (Thromb Res 2010;126:543)
  • Then detect multimers using radiolabeled or enzyme linked anti-vWF antibody
  • Normal in von Willebrands disease types 1, 2N or 2M (type 1 has reduced quantity of all sizes, but difficult to identify on gel)
  • No / reduced high molecular weight multimers in types 2A and 2B von Willebrands disease
  • No / reduced intermediate molecular weight multiples in type 2A
  • No / marked reduction in all multimers in type 3