Coagulation
Coagulation laboratory tests
von Willebrand factor multimer analysis



Topic Completed: 1 November 2012

Revised: 7 January 2019, last major update November 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: von Willebrand factor multimer analysis


Page views in 2019: 124
Page views in 2020 to date: 56
Table of Contents
Definition / general
Cite this page: Parsons J. von Willebrand factor multimer analysis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coagulationvWFmultimers.html. Accessed June 7th, 2020.
Definition / general
  • To detect type 2 von Willebrand disease
  • Involves separation of multimers by size using agarose gel electrophoresis of patients plasma (Thromb Res 2010;126:543)
  • Then detect multimers using radiolabeled or enzyme linked anti-vWF antibody
  • Normal in von Willebrands disease types 1, 2N or 2M (type 1 has reduced quantity of all sizes, but difficult to identify on gel)
  • No / reduced high molecular weight multimers in types 2A and 2B von Willebrands disease
  • No / reduced intermediate molecular weight multiples in type 2A
  • No / marked reduction in all multimers in type 3
Back to top