Colon nontumor
Congenital anomalies
Epidermolysis bullosa dystrophica

Topic Completed: 1 May 2013

Revised: 7 January 2019, last major update May 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Epidermolysis bullosa dystrophica

Hanni Gulwani, M.B.B.S.
Page views in 2018: 156
Page views in 2019 to date: 159
Cite this page: Gulwani H. Epidermolysis bullosa dystrophica. website. Accessed December 14th, 2019.
Definition / general
  • Commonly causes constipation
Case reports
  • 35 year old man with fecal impaction causing toxic megacolon and death from perforation (BMC Dermatol 2006;6:2)
Microscopic (histologic) description
  • Colonic biopsy: abundance of karyorrhectic cellular debris is located within lamina propria (beneath the surface epithelium); patchy granular brown, hemosiderin pigment containing macrophages in lamina propria (J Clin Pathol 2007;60:843)
Microscopic (histologic) images

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Colonic mucosal biopsy specimens

Positive stains
  • Type VII collagen (COL7) is expressed in different portions of gut and anti-COL7 antibodies may induce GI damage (J Pathol 2011;224:234)
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