Table of ContentsDefinition / general | Epidemiology | Etiology | Clinical features | Diagnosis | Treatment | Diagrams / tables | Microscopic (histologic) images | Additional references
Cite this page: Inflammatory bowel disease-general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colonIBCgeneral.html. Accessed July 23rd, 2018.
Definition / general
- Possible causes: alteration in usual steady state between immune system (activated by microbes, antigens and endogenous inflammatory stimuli) and host defenses that maintain integrity of mucosa and down-regulate inflammation (Inflamm Bowel Dis 2006;12:S3, Nat Clin Pract Gastroenterol Hepatol 2006;3:390)
- Often coexists with diverticular disease; presence of Crohn's in diverticular disease is suggested by fissuring ulcers, ulcers outside areas of active diverticulitis and fistulas other than colovesicle or colovaginal; most patients don't develop other IBD lesions
- Requires clinicopathologic correlation; pathologist should convey histologic findings to clinician, who correlates with clinical history, endoscopy, radiology; disease may be difficult to classify (Histopathology 2006;48:116)
- Immunosuppressive therapy