Colon non tumor
Nonneoplastic, noncongenital lesions
Angiolymphoid hyperplasia with eosinophilia

Topic Completed: 1 July 2013

Revised: 9 January 2019, last major update July 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: angiolymphoid hyperplasia with eosinophilia colon

Raul S. Gonzalez, M.D.
Page views in 2019: 284
Page views in 2020 to date: 69
Cite this page: Gonzalez R. Angiolymphoid hyperplasia with eosinophilia. website. Accessed April 6th, 2020.
Definition / general
  • Proliferation of blood vessels with associated lymphoid tissue, including conspicuous eosinophils
  • Also called epithelioid hemangioma (do not confuse with epithelioid hemangioendothelioma)
  • Benign; unclear whether reactive or neoplastic
Clinical features
  • Mass lesion; patients may have peripheral eosinophilia; can cause gastrointestinal bleeding
Case reports
  • Surgical excision
Gross description
  • Mass lesion that may be hemorrhagic
Microscopic (histologic) description
  • Sheets of lymphocytes and eosinophils associated with vessels containing plump and pleomorphic endothelial cells
Microscopic (histologic) images

Images hosted on other servers:

Lobular inflammatory infiltrate

Dense infiltrate with adjacent distorted vessel

Vessels lined by hobnail epithelial cells

Artery at base of lesion
shows severe distortion and
reduplication of internal elastic lamina

Positive stains
Differential diagnosis
  • Epithelioid angiosarcoma: also rare in colon, but distinctly malignant
  • Epithelioid hemangioendothelioma: rarely if ever occurs in the colon
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