Colon non tumor
Nonneoplastic, noncongenital lesions
Barium granuloma

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 11 January 2017, last major update August 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: barium granuloma
Cite this page: Barium granuloma. website. Accessed July 23rd, 2018.
Definition / general
  • Reactive response to barium sulfate implantation underneath colonic mucosa
  • Rare
  • Can occur anywhere in colon
  • May occur after barium enema if barium penetrates mucosal tear and stimulates a granulomatous reaction
Clinical features
  • Usually an incidental finding; may occur in preexisting ulcerated lesions that were evaluated by barium enema; rarely produces polypoid or ulcerated lesion resembling a neoplasm (Dis Colon Rectum 1981;24:388)
  • Electron microscopy can confirm that foreign material is barium
Case reports
Gross description
Microscopic (histologic) description
  • Barium is green, crystalline and refractile; crystals occur in clusters in macrophages or connective tissue and can be observed under polarized light
Microscopic (histologic) images

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High power

Refractile particulate material (Fig 1b)

Additional references