Colon non tumor
Nonneoplastic, noncongenital lesions
Barium granuloma



Topic Completed: 1 August 2013

Revised: 9 January 2019, last major update August 2013

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PubMed Search: barium granuloma

Raul S. Gonzalez, M.D.
Page views in 2018: 249
Page views in 2019 to date: 208
Cite this page: Gonzalez R. Barium granuloma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colonbariumgranulomas.html. Accessed October 13th, 2019.
Definition / general
  • Reactive response to barium sulfate implantation underneath colonic mucosa
Epidemiology
  • Rare
Sites
  • Can occur anywhere in colon
Pathophysiology
  • May occur after barium enema if barium penetrates mucosal tear and stimulates a granulomatous reaction
Clinical features
  • Usually an incidental finding; may occur in preexisting ulcerated lesions that were evaluated by barium enema; rarely produces polypoid or ulcerated lesion resembling a neoplasm (Dis Colon Rectum 1981;24:388)
Diagnosis
  • Electron microscopy can confirm that foreign material is barium
Case reports
Gross description
Microscopic (histologic) description
  • Barium is green, crystalline and refractile; crystals occur in clusters in macrophages or connective tissue and can be observed under polarized light
Microscopic (histologic) images

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Refractile particulate material (Fig 1b)

Additional references
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