Colon non tumor
Colitis (non-infectious)
Behcet's syndrome

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 21 December 2016, last major update May 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: behcet's syndrome
Cite this page: Behcet's syndrome. website. Accessed June 18th, 2018.
Definition / general
  • Multisystem inflammatory disorder of unknown origin, with aphthous stomatitis, genital ulcers, relapsing iritis; also arthritis, cutaneous and vascular disease (eMedicine #1, #2)
  • GI involvement in 10% (ileum, cecum); causes pain, diarrhea, melena; rarely perforation (Surg Today 2003;33:383)
  • More common in region from Mediterranean to eastern Asia
  • 2 / 3 in males
Case reports
  • Steroids
Clinical images

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Punched-out ulcer

Gross description
  • Numerous punched out ulcers of various sizes, shapes and depths in colon
Gross images

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Multiple penetrations


Microscopic (histologic) description
  • Ulcers with neutrophils around ulcer bed, lymphocytic vasculitis in submucosal veins
  • Note: diagnosis is clinical, not histologic
Microscopic (histologic) images

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Loss of normal mucosa

Small vessels have intimal thickening and lymphocytic vasculitis

Congestion, exudate and ulcer base with inflammation

Differential diagnosis