Colon nontumor
Colitis (non-infectious)
Brainerd diarrhea



Topic Completed: 1 May 2013

Revised: 8 January 2019, last major update May 2013

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PubMed Search: brainerd diarrhea

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Brainerd diarrhea. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colonbrainerd.html. Accessed December 13th, 2019.
Definition / general
  • Chronic watery diarrhea of unknown etiology with acute onset and long duration (Centers for Disease Control, Wikipedia)
  • First case in 1983 in Brainerd, Minnesota (USA)
  • Similar to epidemic infectious diarrhea, but symptoms usually last 4+ weeks, often years
  • Most patients recover within 3 years or less
Case reports
Microscopic (histologic) description
  • Surface epithelial lymphocytosis (similar to lymphocytic colitis) with no architectural distortion, no degenerative changes, no thickened subepithelial collagen (Am J Surg Pathol 1996;20:1102)
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