Colon nontumor
Nonneoplastic, noncongenital lesions
Colitis cystica profunda

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 13 July 2018, last major update August 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: colitis cystica profunda
Cite this page: Gonzalez, R.S. Colitis cystica profunda. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/coloncystitiscystica.html. Accessed September 22nd, 2018.
Definition / general
  • Reactive mucosal change characterized by submucosal mucin filled cysts lined by benign epithelium
Terminology
  • Also called colitis cystica polyposa or hamartomatous inverted polyp when presents as polypoid lesion
Epidemiology
  • Uncommon; male predilection
Sites
  • Can occur anywhere in GI tract, including stomach ("gastritis cystica profunda") and small intestine ("enteritis cystica profunda")
Pathophysiology
  • Secondary to mucosal damage due to ulcerative colitis, Crohn disease, radiation, diverticulitis or other inflammation / ulceration of bowel; mucus follows granulation tracts to involve large areas of bowel
Clinical features
  • Stools contain blood or mucus; patients may have diarrhea or abdominal pain
Radiology description
Radiology images

Images hosted on other servers:

Barium imaging shows filling defect

Case reports
Treatment
  • Patient education to avoid straining, high fiber diet with bulk laxatives, surgery for rectal prolapse
Clinical images

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Submucosal abnormality

Gross description
  • May appear as a polypoid or submucosal mass
Microscopic (histologic) description
  • Either localized or diffuse; similar histology to colorectal polyps in Cowden syndrome although "inverted"
  • Misplaced benign colonic epithelium forming cystic spaces filled with mucin and surrounded by lamina propria; mucin may extravasate into surrounding tissue
Differential diagnosis