Colon (tumor & nontumor)
Other nonneoplastic
Elastofibromatous change

Topic Completed: 1 September 2013

Revised: 9 January 2019, last major update September 2013

Copyright: (c) 2003-2017,, Inc.

PubMed Search: elastofibromatous

Raul S. Gonzalez, M.D.
Page views in 2019: 967
Page views in 2020 to date: 573
Cite this page: Gonzalez R. Elastofibromatous change. website. Accessed August 10th, 2020.
Definition / general
  • Uncommon; increase in elastin fibers in colonic submucosa
  • Also called elastosis
  • Called elastofibroma if forms a polyp
  • Occurs throughout gastrointestinal tract
  • In colon, favors left side; can present in rectum
Clinical features
  • Patients typically older than 45
  • No sex predilection
  • May cause nonspecific gastrointestinal symptoms or be asymptomatic
Case reports
Gross description
  • May appear as a polyp or as a linear white lesion
Microscopic (histologic) description
  • Eosinophilic to gray amorphous material, sometimes with fibrous tissue, involving submocusa or muscularis mucosae
  • May be centered around blood vessels (Am J Clin Pathol 2004;122:232)
Microscopic (histologic) images

Images hosted on other servers:

Submucosal elastofibromatous change mimicking amyloid

Elastin stain

Positive stains
  • Elastin stain highlights elastic fibers
Negative stains
Differential diagnosis
  • Amyloidosis: shows birefringence with Congo red stain
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