Colon nontumor
Nonneoplastic, noncongenital lesions
Fibrosing colonopathy

Author: Raul S. Gonzalez, M.D. (see Authors page)

Revised: 13 July 2018, last major update August 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: fibrosing colonopathy
Cite this page: Gonzalez, R.S. Fibrosing colonopathy. website. Accessed July 21st, 2018.
Definition / general
  • Fusiform strictures of the colon; associated with childhood cystic fibrosis
  • Affects right colon or entire colon; distal ileum may be involved but rectum typically spared
  • May be due to ingestion of high doses of high strength pancreatic supplements (associated with cystic fibrosis), perhaps because of the methacrylic acid copolymer coating the medication (Pharmacoepidemiol Drug Saf 1999;8:377)
Clinical features
  • Abdominal pain and distension, constipation, vomiting, bloody diarrhea
Radiology description
  • Loss of haustration on barium study; diffuse colonic narrowing and shortening, with rectal sparing
Case reports
Gross description
  • Cobblestone appearance of colonic mucosa; increased wall thickness
Microscopic (histologic) description
  • Severe submucosal fibrosis with thickening of muscularis propria and chronic mucosal inflammation, including eosinophils and mast cells; variable active cryptitis
Microscopic (histologic) images

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Mucosal inflammation and submucosal fibrosis