General
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• Gastric tissue aberrantly present in colon
• See also heterotopia topic

Epidemiology
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• < 50 cases reported

Sites
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• Usually in rectum; can be multifocal (Gut 1988;29:848)

Clinical features
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• Mean age 18 years, but wide range
• Slight male predominance
• Associated with other heterotopias, with vertebral and digital anomalies
• In rectum, usually presents with rectal bleeding and tenesmus (J Clin Gastroenterol 1994;19:41)
• At colonoscopy, may appear as polyp, ulcer, or diverticulum

Case reports
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• 34 year old man and 36 year old woman with polypoid lesions in rectum (Arch Pathol Lab Med 1999;123:222)
• 70 year old woman with heterotopia giving rise to adenocarcinoma (Korean J Pathol 2013;47:289)
• Associated with tubulovillous adenoma (N J Med 1995;92:512)

Treatment
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• Excision, H2 blockers

Micro description
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• Gastric tissue (typically oxyntic-type but may be pyloric-type) in colon
• Helicobacter pylori organisms may be present

Micro images
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Gastric and colonic mucosa

Gastric and colonic mucosa

Gastric (left) and colonic (right) mucosae

Gastric mucosa with prominent parietal cells

Heterotopic gastric mucosa with cystic dilatation

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