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Colon non tumor
Congenital anomalies
Hirschsprung’s disease

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 11 May 2013, last major update January 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Pathophysiology
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Clinical features
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Diagnosis
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Criteria of diagnosis

Case reports
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Treatment
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Gross description
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Gross images
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Dilated bowel

Micro description
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Micro images
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Lack of ganglion cells

Increased acetylcholine positive nerve fibers

Hyperplastic nerves but no ganglion cells-1


Hyperplastic nerves but no ganglion cells-2

Reduced interstitial cells of Cajal

Suction rectal biopsy specimen

Frozen sections

Segment of ileum and colon


Slide tray

Ganglion cells

Various images

Calretinin


Normal colon - calretinin+

Calretinin expression

Transitional zone - calretinin+



Normal ganglion cells:

Sympathetic ganglion cells

Dorsal root of spinal cord


Virtual slides
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Hirschsprung’s disease

Positive stains
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Negative stains
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Calretinin, S100, NSE, and c-kit expression

Electron microscopy description
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End of Colon non tumor > Congenital anomalies > Hirschsprung’s disease


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